Jeuveau vs. Botox: What’s the Difference?

The world of anti-aging cosmetic treatments is full of options, and choosing the right one can feel overwhelming. When it comes to wrinkle reduction, Botox Cosmetic might be the most well-known injectable treatment–yet a host of other options like Dysport, Xeomin and Jeuveau promise the same results. 

Both Jeuveau and Botox utilize botulinum toxin, a purified protein, to temporarily relax facial muscles and reduce the appearance of wrinkles. But with so much information available, it’s natural to wonder what the differences are between them.

Here, we’re deep-diving into Jeuveau and Botox, discussing what makes each unique and why you might opt for one over the other.

Understanding Neurotoxin Treatments

Before getting into the specifics of Jeuveau and Botox, let’s explore how these treatments work. Injectable neurotoxins, also known as neuromodulators, are derived from a purified protein found in botulinum toxin type A. When injected into targeted facial muscles, they work by temporarily blocking nerve signals that cause muscle contractions. This relaxation of muscles helps to smooth out fine lines and creases, particularly those caused by facial expressions.

Botox: the original wrinkle reducer

Botox (onabotulinumtoxinA), produced by Allergan, holds the title of the first FDA-approved botulinum toxin for cosmetic use. Its story began in the medical field, treating conditions like crossed eyes, migraines and hyperhidrosis (excessive sweating). However, doctors soon noticed an unexpected benefit–patients were experiencing a reduction in facial wrinkles. 

This discovery revolutionized the anti-aging industry, and Botox remains a leading choice for non-surgical wrinkle reduction due to its extensive track record and proven effectiveness.

Jeuveau: a new generation of neurotoxin

Nicknamed “Newtox,” Jeuveau (prabotulinumtoxinA) is a fresh face in the world of cosmetic injectables. Unlike Botox, which began its journey in the medical field, Jeuveau was developed specifically for aesthetic use by Evolus, a South Korea-based company. This targeted focus translates to an FDA-approved treatment specifically designed to tackle facial wrinkles.

Similarities Between Jeuveau and Botox

Despite their distinct origins, Jeuveau and Botox share core functionalities that make them both effective weapons in the fight against wrinkles.

Mechanism of action

Both treatments leverage the power of botulinum toxin type A, a purified protein that works its magic by temporarily disrupting the communication between nerves and muscles. This disrupts the signals that trigger muscle contractions, leading to a relaxation of targeted facial muscles. By achieving this relaxation, Jeuveau and Botox can effectively smooth out wrinkles and creases, particularly those that become more prominent with facial expressions like frowning, squinting or smiling.

Cosmetic uses

Jeuveau and Botox share a common ground in their ability to address a variety of visible facial wrinkles. Popular treatment areas include:

  • Forehead Lines: Those horizontal creases that furrow across the forehead, often a result of repeated squinting or raising eyebrows. 
  • Crow’s Feet: The delicate fan-like lines radiating from the outer corners of the eyes, often formed through years of smiling or squinting. 
  • Glabellar Lines: The vertical lines that furrow between the eyebrows, sometimes referred to as frown lines or “11” lines due to their shape.

In many cosmetic applications, Jeuveau and Botox can be considered interchangeable options. The choice between them might depend on the injector’s experience and familiarity with each product, as well as your individual response to the treatment. 

Side effects and safety profiles

Both Jeuveau and Botox boast a strong safety profile when administered by qualified professionals. Extensive clinical trials and ongoing monitoring have shown minimal risks. While temporary side effects like bruising, swelling or redness at the injection site are possible, they typically resolve on their own within a few days.

Cost comparison

The cost of Jeuveau and Botox treatments can vary depending on several factors, including: 

  • Geographic Location: Prices can fluctuate based on the cost of living in your area.
  • Practitioner Fee: The experience and expertise of the injector can influence the treatment cost.
  • Number of Units Required: The number of units needed depends on the severity of wrinkles and the desired results. Generally, more units translate to a higher cost.

It’s important to consult with a qualified provider to receive an accurate price estimate for your specific needs.

Duration and onset of results

Both Jeuveau and Botox are relatively fast-acting, with results peeking through within a few days to two weeks. The effects typically last 3 to 6 months, but it depends on a few factors. A faster metabolism might mean more frequent touch-ups. Areas with less movement, like the forehead, hold onto the effects longer than areas that move more, like around the eyes. Smoking and sun exposure can also shorten the lifespan of your results.

Key Differences Between Jeuveau and Botox

While they share many similarities, Jeuveau and Botox injections have some key distinctions.


Both have a version of botulinum toxin type A as the active ingredient, but subtle differences exist in their proprietary formulations. These variations in protein composition and manufacturing processes may slightly affect how the product distributes and works within the body.

Clinical trials 

Jeuveau’s FDA approval was based on clinical trials specifically designed to assess its safety and efficacy for cosmetic applications. Conversely, Botox’s cosmetic use was discovered through its therapeutic applications, leading to a broader range of clinical data spanning various medical conditions.

Indicated uses

While Botox has FDA-approval for multiple medical and cosmetic purposes, Jeuveau has technically only been approved to treat glabellar lines. However, it’s used off-label for almost all the same applications as Botox, a practice that is considered safe in the industry.

Approval history

Botox boasts a longer history, having gained FDA approval for cosmetic use in 2002. It also holds a wider range of approved therapeutic and cosmetic indications. Jeuveau’s approval came later in 2019, with a focus primarily on cosmetic applications, specifically for glabellar lines.

Making the Right Choice for You

Choosing between Jeuveau and Botox depends on several factors:

Specific treatment goals 

Consider the specific areas you wish to target and the desired outcome. The subtle differences in formulations might make one product more suitable for certain areas or types of wrinkles. For instance, if you’re primarily concerned with glabellar lines, Jeuveau might be a good choice due to its specific FDA approval for that area.

Cost and accessibility

Evaluate the cost-effectiveness of each option based on treatment pricing in your area and the potential need for touch-up treatments. Jeuveau injections may sometimes be offered at a slightly lower price point than Botox. However, the need for more frequent touch-ups due to individual response could negate any initial cost savings.

Provider expertise

Choose a product based on the experience and preference of the healthcare provider administering the treatment. Their familiarity with a particular neurotoxin can influence the effectiveness and safety of the procedure.

The Bottom Line

While both Jeuveau and Botox are effective wrinkle reducers, some key distinctions set them apart. Jeuveau, a “Newtox” designed specifically for aesthetics, has FDA approval for treating glabellar lines. Botox, with a longer history, has a wider range of approved therapeutic and cosmetic uses. Their formulations and clinical trial data also differ slightly.

However, the similarities are significant. Both utilize botulinum toxin to relax muscles and smooth wrinkles, particularly in areas like the forehead, crow’s feet and between the brows. They share similar safety profiles and potential side effects when administered by qualified professionals.

So, which one is right for you? There’s no single answer. The best choice depends on your individual needs and how you respond to the treatment. That’s why consulting a board-certified or licensed professional at a reputable medical spa is key–they can evaluate your unique concerns and skin anatomy and discuss the pros and cons of Jeuveau, Botox and even alternative cosmetic procedures like fillers, microneedling or laser treatments. Then, based on that assessment, they can create a personalized plan to achieve your aesthetic goals.

Don’t hesitate to ask questions! Open communication with your provider ensures you feel confident about your decision. Ultimately, the goal is to achieve natural-looking, rejuvenated results that leave you feeling beautiful in your own skin.

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